Polygenic Scores: Why The Hype?
A single number, thousands of variants — but does the promise match the science? (📷:empowervmedia) I magine a single number that claims to predict your risk of depression, your expected years of schooling, or your likelihood of a heart attack — derived entirely from your DNA. That is the promise of the polygenic score (PGS): a summary statistic aggregating the influence of thousands of common genetic variants into one figure. Since their first systematic development in 2009, over 1,000 peer-reviewed publications have employed this methodology - spanning schizophrenia, educational attainment, and alcohol misuse. The scientific appeal is genuine. The hype surrounding it, however, demands scrutiny. Polygenic scores are statistical predictors , not biological verdicts. Within the populations for which they were built, their explanatory power can be notable - reaching up to 13% of variance explained for educational attainment and 24% for height (Mostafavi et al., eLi...